Monday Night Football Odds & Predictions 2025: Texans, Chargers Favorites in Doubleheader
We're treated to a true doubleheader on ESPN to cap the NFL's Week 2, and the Houston Texans (-2.5) and Los Angeles Chargers (-3.5) are the betting favorites by the Monday Night Football odds against the Tampa Bay Buccaneers and Las Vegas Raiders, respectively.
We'll have NFL picks for both games as part of our NFL predictions for Week 2.
๐ MNF Week 2 odds: Buccaneers vs. Texans (-2.5)
The Texans remain a home favorite against the Buccaneers in Monday night's first game (7 p.m. ET, ESPN and ABC). The spread actually swung a point in their favor from the opening betting line of 1.5m despite a Week 1 loss to the Los Angeles Rams on the road.
The Bucs beat the Atlanta Falcons on the road, benefiting from a late Falcons penalty and a missed field goal. The Over/Under of 42.5 is one of the lowest among the NFL Week 2 odds. Our Mike Spector is backing the Over with his early Buccaneers vs. Texans prediction.
Buccaneers vs. Texans odds
Our NFL odds update in real time and show the best line/odds for either side of the spread, Over/Under, and moneyline:
๐ MNF Week 2 odds: Chargers (-3.5) vs. Raiders
The Chargers and Raiders were both victorious in Week 1, and Los Angeles enters Week 2 as the betting favorite while coming off the more impressive win. The spread has swung slightly to the Chargers, which was featured in Gary Pearson's NFL picks against the spread and early Chargers vs. Raiders prediction.
Chargers vs. Raiders odds
๐ฎ Monday Night Football predictions
Here are our betting experts' NFL picks for the Monday Night Football doubleheader:
Buccaneers vs. Texans predictions:
Buccaneers +2.5 (-115) via C Jackson Cowart: "Both of these teams face issues after uninspiring Week 1 efforts, but the Texans' offensive line is a concern I'm unwilling to overlook - especially against a Todd Bowles-led defense out for blood."
Over 44.5 (-103) via Mike Spector: "I get the publicโs initial reaction to loving the Under for next week, especially after Houston committed two turnovers and punted twice on its four second-half possessions in Week 1. But I am buying low on its offense, especially if it gets some key skill position players like Christian Kirk or Braxton Berrios back for next week."
Chargers vs. Raiders predictions:
Chargers -3 (-115) via Gary Pearson: The Chargers were 7-2 ATS on the road last season, 6-1 ATS as the betting favorite on enemy territory, and 2-0 ATS against the Raiders. Admittedly, this Raiders team is substantially better than last season's. Still, the Chargers appear ready to take the next step, and they should bring the Raiders back down to earth in Week 2.
Ladd McConkey to score a touchdown (+155) via Dustin Saracini: "Ladd McConkey burst onto the scene and has become one of the best possession receivers in the NFL. Justin Herbert clearly loves him, too, registering nine targets on six catches for 74 yards in Week 1. He'll find him in the end zone in Week 2."
๐ Monday Night Football betting results
Here are the results of the spread and Over/Under from every completed Monday Night Football game this season:
| Week | Matchup | Spread | Over/Under |
|---|---|---|---|
| 1 | Vikings vs. Bears | Vikings +1.5 | O43.5 |
๐๏ธ Monday Night Football 2025 schedule
Opening Monday Night Football NFL odds for the 2025 season regular season are via DraftKings.
| Week | Matcup | Opening spread | Opening Over/Under |
|---|---|---|---|
| 2 (Sept. 15) | Buccaneers vs. Texans | Texans -1.5 | 46.5 |
| 2 (Sept. 15) | Chargers vs. Raiders | Chargers -3 | 44.5 |
| 3 (Sept. 22) | Lions vs. Ravens | Ravens -3.5 | 49.5 |
| 4 (Sept. 29) | Jets vs. Dolphins | Dolphins -5.5 | 44.5 |
| 4 (Sept. 29) | Bengals vs. Broncos | Broncos -2.5 | 47.5 |
| 5 (Oct. 6) | Chiefs vs. Jaguars | Chiefs -4.5 | 47.5 |
| 6 (Oct. 13) | Bills vs. Falcons | Bills -5.5 | 48.5 |
| 6 (Oct. 13) | Bears vs. Commanders | Commanders -4.5 | 48.5 |
| 7 (Oct. 20) | Buccaneers vs. Lions | Lions -3.5 | 49.5 |
| 7 (Oct. 20) | Texans vs. Seahawks | Seahawks -1.5 | 44.5 |
| 8 (Oct. 27) | Commanders vs. Chiefs | Chiefs -3.5 | 48.5 |
| 9 (Nov. 3) | Cardinals vs. Cowboys | Cowboys -1.5 | 47.5 |
| 10 (Nov. 10) | Eagles vs. Packers | Eagles -1.5 | 45.5 |
| 11 (Nov. 17) | Cowboys vs. Raiders | Cowboys -1.5 | 45.5 |
| 12 (Nov. 24) | Panthers vs. 49ers | 49ers -7 | 46.5 |
| 13 (Dec. 1) | Giants vs. Patriots | Patriots -3 | 42.5 |
| 14 (Dec. 8) | Eagles vs. Chargers | Eagles -2.5 | 45.5 |
| 15 (Dec. 15) | Dolphins vs. Steelers | Steelers -2.5 | 44.5 |
| 16 (Dec. 22) | 49ers vs. Colts | 49ers -3 | 46.5 |
| 17 (Dec. 29) | Rams vs. Falcons | Rams -3 | 46.5 |
Don't miss our lists of the best NFL parlay betting sites and top NFL prop betting sites!
๐ง Monday Night Football betting tips
Get an early start
The Monday Night Football game is a big deal for betting each week. This brings lots of bets and changes in the odds, especially from those chasing their losses after a tough Sunday betting slate. Watch the lines and totals when they start. If they go the way you like, you can wait. If they move against you, think about acting sooner.
Embrace in-game betting
While you might struggle to find value in the most popular markets for any marquee prime-time NFL game, you're sure to unearth some worthwhile plays once the game starts. Live betting might not be your thing when there are a handful of games going on at the same time, but Monday Night Football is the perfect time to lay into some live action via our best live betting sites.
Be wary of winter weather
Things can get pretty frightful outside later in the NFL season โ particularly when the sun goes down. Our guide on how to bet on the NFL offers tips for how to approach betting on cold-weather games.
Check out our list of the best sportsbook promos here!
โMonday Night Football FAQs
Who is favored on Monday Night Football this week?
The Houston Texans are a 2.5-point home favorite against the Tampa Bay Buccaneers in Monday's 7 p.m. ET game. The Los Angeles Chargers are a 3.5-point betting favorite against the Las Vegas Raiders with a 10 p.m. ET kickoff.
How do I watch Sunday Night Football?
Monday Night Football is broadcast on ESPN with some doubleheaders appearing on ABC.
Who are the announcers on Monday Night Football?
Joe Buck and Troy Aikman are the current commentators for Monday Night Football on ESPN. Laura Rutledge and Lisa Salters are the sideline reporters, and Russell Yurk is the rules analyst on the broadcast.
Who will make the most Monday Night Football appearances in 2025?
No team will make more than two appearances on Monday Night Football season.
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