Today's Best Aryna Sabalenka vs. Amanda Anisimova Predictions & Odds: US Open Women's Final

Last Updated: September 6, 2025 2:20 PM EDT • 4 minute read X Social Google News Link

Amanda Anisimova will try to become the second American woman in the last eight years to take the US Open, while world No. 1 Aryna Sabalenka is seeking to be the first repeat US Open women’s champion since Serena Williams. The two will clash in today's US Open women's final, and I analyze it in my Aryna Sabalenka vs. Amanda Anisimova predictions.
Sabalenka is the -200 betting favorite for the US Open final, which takes place at 4 p.m. ET today from Arthur Ashe Stadium in Flushing Meadows, N.Y. (ESPN).
💰 Aryna Sabalenka vs. Amanda Anisimova predictions
- Pick to win: Amanda Anisimova (+187 via bet365) ⭐⭐⭐⭐⭐
- Best pick: Amanda Anisimova +3.5 games (-110 via FanDuel) ⭐⭐⭐⭐⭐
Read on for the latest odds and full analysis of our best bets, and don't miss Gary Pearson's Jannik Sinner vs. Carlos Alcaraz prediction.
🏆 Aryna Sabalenka vs. Amanda Anisimova pick to win

Amanda Anisimova ⭐⭐⭐
Aryna Sabalenka is the rightful favorite with this being her third major final this year, and sixth straight final at a hard court major. She also enters this matchup amid a 12-match US Open winning streak, and is the first woman to advance to three straight US Open finals since 2014.
Amanda Anisimova has been the more doubted player through this entire run, especially entering her match against Iga Swiatek, who she embarrassingly lost to 6-0, 6-0 in the Wimbledon final. But Anisimova not only passed that test in the quarterfinals, she also knocked off Naomi Osaka, who had not lost a Grand Slam match in the previous four majors when she reached the semifinal.
Anisimova is the one player on tour who can consistently hit ground strokes harder than Sabalenka, so the world No. 1 loses a key advantage she has on every other opponent.
The American has won six of the nine head-to-head matches and leads 3-to-2 in majors.
Sabalenka is now the one who should have questions and doubts looming, as she has made the semifinals or better in every Grand Slam this season, but hasn’t won a title.
The best value for Anisimova moneyline backers is at bet365, the only one of the best sports betting sites offering better than a price of +180. Through the +187 odds, a $10 winning wager would net $18.70 in profits compared to the $16 profits through the +160 odds on the low end of the market.
✅ Best Aryna Sabalenka vs. Amanda Anisimova pick
Amanda Anisimova +3.5 games ⭐⭐⭐⭐⭐
After picking Anisimova to win outright, backing her on the games spread is a great way to double down, but still offers value even if she does lose the match.
Sabalenka has failed to cover the game spread in each of her previous 10 Grand Slam matches. Anisimova is also a great bet to win at least one set given that four of Sabalenka’s previous six finals at Grand Slams have gone to three sets. Lastly, the Over on total games is 14-1 in Sabalenka’s last 15 Grand Slam matches.
The longer this match goes, the more difficult it will be for Sabalenka to cover.
The +3.5 games spread is juiced as high as -125 at Caesars, so I am headed to FanDuel for the best return. At -110 odds, a $10 winning wager would net $9.09 in profits.
📊 Aryna Sabalenka vs. Amanda Anisimova odds
Odds via DraftKings; pick confidence based on a 1-to-5-star scale.
Aryna Sabalenka | Amanda Anisimova | |
---|---|---|
Moneyline | -200 | +160 |
Spread | -3.5 (+100) | +3.5 (-135) |
Over/Under | Over 22.5 (-110) | Under 22.5 (-110) |
📈 Aryna Sabalenka vs. Amanda Anisimova betting insights
Here are some betting insights from BetMGM in the hours before the match.
- Sabalenka's moneyline odds haven't budged and remain at -200
- There's been minor movement tied to Anisimova, who now sits at +165
- Sabalenka is favored to win the first set at -181, with Anisimova at +130
🆚 Aryna Sabalenka vs. Amanda Anisimova H2H stats
Aryna Sabalenka | Stat | Amanda Anisimova |
---|---|---|
3 | Matches won | 6 |
2 | Wins in straight sets | 3 |
9 | Sets won | 13 |
97 | Games won | 106 |
1 | Wins on hard court | 2 |
📺 US Open final match info
- When: Saturday, Sept. 6 (4 p.m. ET)
- Where: Arthur Ashe Stadium (Flushing Meadows, N.Y.)
- How to watch: ESPN
- Favorite: Aryna Sabalenka (-200 via DraftKings)
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Mike Spector X social