Ole Miss vs. Kentucky Prediction, Odds & Expert Picks: College Football Week 2 Best Bets

Our Ole Miss vs. Kentucky prediction looks at the only SEC conference game among our college football picks and college football predictions for Week 2. Is revenge coming after the Wildcats shocked the Rebels to end Ole Miss' CFP aspirations last year?

Today's game kicks off this afternoon at 3:30 p.m. ET (ABC) from Kroger Field in Lexington, Ky.

With Ole Miss as an 8.5-point betting favorite at our best sports betting sites, my top player prop involves a likely explosive day for Austin Simmons.

🏈 Ole Miss vs. Kentucky prediction

College football expert picks made Friday; odds subject to change.

• Moneyline pick: Ole Miss (-330 via FanDuel) ⭐⭐⭐⭐
• Against the spread pick: Ole Miss -8.5 (-110 via FanDuel) ⭐⭐⭐⭐⭐
• Over/Under pick: Over 50.5 (-105 via BetMGM) ⭐⭐⭐⭐

📝 Ole Miss vs. Kentucky preview & best bet

Track the latest college football scores for line movement and matchup info.

🦈 Ole Miss -8.5 (-110) ⭐⭐⭐⭐⭐

Georgia State found success on the ground against Ole Miss in the opener, which could be good news for Kentucky’s solid rushing attack that Dante Dowdell and Seth McGowan lead. But to hang with Ole Miss, the Wildcats will need Zach Calzada to make plays with his arm.

But I’m not convinced Calzada can do it after an 85-yard performance in which he completed fewer than 50% of his pass attempts against Toledo. Ole Miss dropped 695 yards of total offense on Georgia State, which tells me the Rebels may punish Kentucky’s defense as retribution for the Wildcats’ upset win in Oxford last fall.

FanDuel lists the most favorable line for those looking to back the Rebels, featuring Ole Miss -8.5 at -110 betting odds. This equates to an implied probability of 52.38%. A winning $10 wager on Ole Miss would translate to a $9.09 profit.

💰 Best Ole Miss vs. Kentucky player prop bet

Our college football player prop odds tool shows the best odds for every market across legal sportsbooks in your area.

⬆️ Austin Simmons Over 260.5 passing yards (-114) ⭐⭐⭐⭐⭐

New Rebels QB Austin Simmons paced the Ole Miss aerial attack with 341 yards and three touchdowns last week during a rout of Georgia State.

He needs to take better care of the football than Simmons did while throwing two interceptions in that contest. But the dynamic gunslinger should make the Rebels' offense hum against a Kentucky secondary that allowed 270 passing yards to Toledo in a Week 1 gutcheck.

FanDuel’s line on Simmons’ passing yardage (260.5 yards) is more favorable for Over bettors than the price at BetMGM (275.5 yards). The -114 odds on Over 260.5 yards at FanDuel equate to an implied probability of 53.27%. A winning $10 wager on this prop would profit $8.77.

📊 Ole Miss vs. Kentucky odds: Week 2

College football odds update live in real time.

📈 Ole Miss vs. Kentucky opening odds

• Moneyline: Ole Miss +400 | Kentucky -310
• Spread: Ole Miss -9.5 (-115) | Kentucky -9.5 (-105)
• Over/Under: Over 52.5 (--110) | Under 52.5 (-110)

🔍 Ole Miss vs. Kentucky odds analysis

After opening at Ole Miss -9.5, we’ve seen movement toward Kentucky across our best sports betting apps. Lines now sit between Ole Miss -8.5 and -9, which feels understandable since it’s a conference game for the Wildcats at home.

Still, I wouldn’t be surprised to see the market shift narrowly back toward the original line prior to kickoff, which makes the current offering at FanDuel (-8.5) a solid value.

📈 Ole Miss vs. Kentucky betting insights

Here are some betting insights from BetMGM in the hours before kickoff.

• Ole Miss is generating 80% of the bets and 61% of the handle to cover -9.5
• The betting is more narrow on the total, with the Under getting 55% of the bets and 52% of the total
• Kentucky is drawing 53% of the bets as the moneyline underdog at +280, though Ole Miss is receiving 82% of the handle

🔢 Ole Miss vs. Kentucky stats

Season stats courtesy of Sports Reference.

📺 Ole Miss vs. Kentucky game info

• When: Saturday, Sept., 6
• Kickoff: 3:30 p.m. ET
• Where: Kroger Field (Lexington, Ky.)
• How to watch: ABC

❓ Ole Miss vs. Kentucky FAQs

Who is favored to win Ole Miss vs. Kentucky?

Ole Miss is favored to win the game with -330 odds on the moneyline at FanDuel, down slightly from the opening odds of -400.

What is the spread for Ole Miss vs. Kentucky?

The spread for Ole Miss vs. Kentucky has the Rebels favored by between 8.5 and 9 points after opening as 9.5-point betting favorites.

What is the Over/Under for Ole Miss vs. Kentucky?

The Over/Under for Ole Miss vs. Kentucky is 50.5, which is down slightly from the opening total of 52.5.

What are the best bets for Ole Miss vs. Kentucky?

My best bets for Ole Miss vs. Kentucky include Ole Miss -8.5 (-110 via FanDuel) and Austin Simmons Over 260.5 passing yards (-114 via FanDuel).

When is the Ole Miss vs. Kentucky game?

Ole Miss vs. Kentucky starts at 3:30 p.m. ET on Saturday, Sept. 6, and will be televised on ABC.

How do college football odds work?

When betting on college football, the point spread shows how many points the favorite needs to win by in order to cash the bet. For example, a favorite of -3 must win by more than 3 points to cover the spread, while an underdog at +3 must win outright or lose by fewer than 3 points to cover the spread.

Moneyline odds represent the payout for picking the outright winner (+200 means a $100 bet wins $200, while -200 means a $200 bet wins $100). Over/Unders let you wager on whether the combined total will be higher or lower than the set number.

You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.

(21+. Gambling Problem? Call 1-800-GAMBLER)
* Bonuses not applicable in Ontario.

Not intended for use in MA.
Each betting site featured on SBR has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.