College Football Opening Odds for Week 3: Betting Lines for Top 25 Matchups

Check out the opening odds for college football's Week 3 slate with moneylines, spreads, and totals for notable games.

Gabe Henderson

Last Updated: September 8, 2025 9:49 AM EDT • 6 minute read

College Football Opening Odds for Week 3: Betting Lines & Spreads for Ranked Matchups — Pictured: Florida Gators quarterback DJ Lagway (2) calls a play against the LSU Tigers. Photo by Kim Klement Neitzel via Imagn Images.

College football odds for Week 3

The opening college football odds for Week 3 are via FanDuel.

Game	Spread	Moneyline	Over/Under
No. 4 Oregon vs. Northwestern	Oregon -27.5	Oregon -7000	50.5
No. 12 Clemson vs. Georgia Tech	Clemson -4.5	Clemson -188	52.5
Central Michigan vs. No. 23 Michigan	Michigan -27.5	Michigan -10000	42.5
No. 13 Oklahoma vs. Temple	Oklahoma -24.5	Oklahoma -4000	51.5
Wisconsin vs. No. 19 Alabama	Alabama -20.5	Alabama -2100	46.5
South Alabama vs. No. 24 Auburn	Auburn -25.5	Auburn -4000	53.5
No. 6 Georgia vs. No. 15 Tennessee	Georgia -4.5	Georgia -205	49.5
Oregon State vs. No. 21 Texas Tech	Texas Tech -24.5	Texas Tech -3000	60.5
No. 14 Iowa State vs. Arkansas State	Iowa State -20.5	Iowa State -1600	55.5
Louisiana-Lafayette vs. No. 25 Missouri	Missouri -24.5	Missouri -4000	48.5
UTEP vs. No. 7 Texas	Texas -41.5	N/A	50.5
No. 18 South Florida vs. No. 5 Miami	Miami -16.5	Miami -690	54.5
Ohio vs. No. 1 Ohio State	Ohio State -33.5	Ohio State -30000	53.5
Arkansas vs. No. 17 Ole Miss	Ole Miss -8.5	Ole Miss -320	62.5
Western Michigan vs. No. 9 Illinois	Illinois -27.5	Illinois -4500	51.5
Florida vs. No. 3 LSU	LSU -9.5	LSU -320	50.5
No. 16 Texas A&M vs. No. 8 Notre Dame	Notre Dame -6.5	Notre Dame -225	48.5
Vanderbilt vs. No. 11 South Carolina	South Carolina -5.5	South Carolina -205	47.5
No. 20 Utah vs. Wyoming	Utah -22.5	Utah -3000	48.5

*-Some top 25 games - such as Indiana State vs. Indiana and Villanova vs. Penn State - do not feature odds due to FCS opposition.

While Week 2 didn't feature many ranked matchups, this wonderfully unpredictable sport delivered once again in a big way. The latest college football betting lines for Week 3 break down the week's slate from a betting perspective, offering game info and the latest lines for the biggest games.

There is plenty of mouthwatering action this weekend, including No. 6 Georgia vs. No. 15 Tennessee, No. 18 South Florida vs. No. 5 Miami, No. 16 Texas A&M vs. No. 8 Notre Dame, and more. Our college football predictions for Week 3 will cover all of these biggest games.

Indiana State vs. Indiana game info

When: Friday, Sept. 12
Kickoff: 5:30 p.m. ET
Where: Memorial Stadium (Bloomington, Ind.)
How to watch: Big Ten Network

Oregon vs. Northwestern odds

When: Saturday, Sept. 13
Kickoff: Noon ET
Where: Northwestern Medicine Field at Martin Stadium (Evanston, Ill.)
How to watch: FOX

Clemson vs. Georgia Tech odds

When: Saturday, Sept. 13
Kickoff: Noon ET
Where: Bobby Dodd Stadium (Atlanta)
How to watch: ESPN

Central Michigan vs. Michigan odds

When: Saturday, Sept. 13
Kickoff: Noon ET
Where: Michigan Stadium (Ann Arbor, Mich.)
How to watch: Big Ten Network

Oklahoma vs. Temple odds

When: Saturday, Sept. 13
Kickoff: Noon ET
Where: Lincoln Financial Field (Philadelphia)
How to watch: ESPN2

Wisconsin vs. Alabama odds

When: Saturday, Sept. 13
Kickoff: Noon ET
Where: Bryant-Denny Stadium (Tuscaloosa, Ala.)
How to watch: ABC

South Alabama vs. Auburn odds

When: Saturday, Sept. 13
Kickoff: 12:45 p.m. ET
Where: Jordan-Hare Stadium (Auburn, Ala.)
How to watch: SEC Network

Villanova vs. Penn State game info

When: Saturday, Sept. 13
Kickoff: 3:30 p.m. ET
Where: Beaver Stadium (University Park, Pa.)
How to watch: FS1

Georgia vs. Tennessee odds

When: Saturday, Sept. 13
Kickoff: 3:30 p.m. ET
Where: Neyland Stadium (Knoxville, Tenn.)
How to watch: ABC

Georgia looks to win its ninth-straight contest against Tennessee. While the Bulldogs are just 4.5-point betting favorites following a sloppy showing against Austin Peay, this is a chance for Kirby Smart's squad to flex its muscles. Meanwhile, this would be a program-defining victory for the Volunteers, who have been relatively overlooked thus far.

Oregon State vs. Texas Tech odds

When: Saturday, Sept. 13
Kickoff: 3:30 p.m. ET
Where: Jones AT&T Stadium (Lubbock, Texas)
How to watch: FOX

Iowa State vs. Arkansas State odds

When: Saturday, Sept. 13
Kickoff: 4 p.m. ET
Where: Centennial Bank Stadium (Jonesboro, Ark.)
How to watch: ESPN2

Louisiana-Lafayette vs. Missouri odds

When: Saturday, Sept. 13
Kickoff: 4 p.m. ET
Where: Memorial Stadium (Columbia, Mo.)
How to watch: ESPN+, SEC Network+

UTEP vs. Texas odds

When: Saturday, Sept. 13
Kickoff: 4:15 p.m. ET
Where: DKR-Texas Memorial Stadium (Austin, Texas)
How to watch: SEC Network

South Florida vs. Miami odds

When: Saturday, Sept. 13
Kickoff: 4:30 p.m. ET
Where: Hard Rock Stadium (Miami Gardens, Fla.)
How to watch: The CW

Miami is on high alert following South Florida's shocking upset of Florida. The Bulls have already knocked off two ranked teams through the first few weeks of the campaign, but the sportsbooks see this as the unlikeliest upset to date. The Hurricanes are 16.5-point home favorites, with heavily juiced odds to remain unbeaten.

Ohio vs. Ohio State odds

When: Saturday, Sept. 13
Kickoff: 7 p.m. ET
Where: Ohio Stadium (Columbus, Ohio)
How to watch: Peacock

Arkansas vs. Ole Miss odds

When: Saturday, Sept. 13
Kickoff: 7 p.m. ET
Where: Vaught-Hemingway Stadium (Oxford, Miss.)
How to watch: ESPN

Western Michigan vs. Illinois odds

When: Saturday, Sept. 13
Kickoff: 7 p.m. ET
Where: Memorial Stadium (Champaign, Ill.)
How to watch: FS1

Florida vs. LSU odds

When: Saturday, Sept. 13
Kickoff: 7:30 p.m. ET
Where: Tiger Stadium (Baton Rouge, La.)
How to watch: ABC

LSU shockingly opened as an 8.5-point betting favorite before Week 2 action. However, following Florida's embarrassing home defeat to South Florida, the odds at the best college football betting sites continued to move in the hosts' favor. The Tigers are now 9.5-point betting favorites over their now-unranked visitors in this rivalry matchup.

Texas A&M vs. Notre Dame odds

When: Saturday, Sept. 13
Kickoff: 7:30 p.m. ET
Where: Notre Dame Stadium (Notre Dame, Ind.)
How to watch: NBC, Peacock

Texas A&M looks to pick up its biggest non-conference victory since before Johnny Manziel stepped foot on campus in College Station. The Aggies are 6.5-point underdogs at No. 8 Notre Dame, who is coming off a heartbreaking defeat at Miami. Oddsmakers expect the hosts to take care of business as -220 betting favorites, but a win would redefine expectations for Mike Elko's men.

See Mike Spector's early Texas A&M vs. Notre Dame prediction for more.

Vanderbilt vs. South Carolina odds

When: Saturday, Sept. 13
Kickoff: 7:45 p.m. ET
Where: Williams-Brice Stadium (Columbia, S.C.)
How to watch: SEC Network

Utah vs. Wyoming odds

When: Saturday, Sept. 13
Kickoff: 8 p.m. ET
Where: War Memorial Stadium (Laramie, Wyo.)
How to watch: CBSSN

College football Week 3 odds and lines

There's an advantage to betting the early college football odds when attempting to beat the closing line. The closer you wait until kickoff to make your college football picks, the more difficult it becomes to identify edges and secure the best price on most sides or totals.

That's why it's important to start monitoring the college football opening odds each week as soon as possible. A proactive approach is the first step to long-term success.

College football odds FAQs

How do college football spread odds work?

When betting on college football, the favorite needs to win by a certain number of points to cover the "point spread" - also known as the betting line. Conversely, the underdog needs to lose by fewer than the points displayed in the spread or win outright to cash. For example, a 3-point favorite would need to win by more than a field goal to reward bettors.

How do college football moneyline odds work?

When betting on college football, the underdog will have the "longer" odds and is typically priced at "plus-money" odds that indicate the profit on a $100 bet. For example, a team with +150 odds would turn a $100 bet into a $150 profit - or a $10 bet into a $15 profit - according to our odds converter.

Where can I find the best college football betting odds?

Shop around our best college football betting sites to find the best odds for your college football picks. Our best sports betting sites for all sports include BetMGM, bet365, Caesars, FanDuel, and DraftKings.

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Written by:
Gabe Henderson

Gabe Henderson is a sports betting writer from Houston, Texas. He graduated from Louisiana State University in 2022 with a bachelor's degree in Mass Communication. Gabe developed an interest in sports betting while in college due to its legalization in Louisiana. He turned his passion into a career shortly after, joining The Advocate/NOLA.com as a Sports Betting Content Coordinator, where he spent two years bulding his college football and NFL experience. Gabe wore many hats before graduating as he led FanSided's coverage of Chelsea FC as a Site Expert with "The Pride of London." He was also the Editor-in-Chief of the LSU Gumbo Yearbook for two years. Gabe became a part of the SportsbookReview.com team in late 2024. He brings with him an extensive knowledge of many sports, including — but not limited to — NFL, NCAA, MLB, NBA, soccer, and UFC.

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