College Football Predictions Week 10: Best Bets & Odds for Friday
 
        
    Last Updated: October 30, 2025 7:39 PM EDT โข 3 minute read X Social Google News Link
 
                                As we head into the final few weeks of the regular season, our college football predictions for Week 10 focus on several key matchups from Weekday CUSA games to the Pac-2 showdown deep into Saturday night.
Our college football picks continue Friday with Memphis vs. Rice at 7 p.m. ET (ESPN2), North Carolina vs. Syracuse at 7:30 p.m. ET (ESPN), and Sam Houston vs. Louisiana Tech at 8 p.m. ET (CBSSN).
๐ College football predictions: Week 10
Here are all of our college football expert picks for Week 10, which we'll update throughout the week.
- Memphis vs. Rice prediction
- North Carolina vs. Syracuse prediction
- North Carolina vs. Syracuse player props (coming soon)
- Sam Houston vs. Louisiana Tech prediction
- Early Penn State vs. Ohio State prediction
- Penn State vs. Ohio State prediction (coming soon)
- Penn State vs. Ohio State player props (coming soon)
- Penn State vs. Ohio State anytime touchdown scorer predictions (coming soon)
- Early Vanderbilt vs. Texas prediction
- Vanderbilt vs. Texas prediction (coming soon)
- Vanderbilt vs. Texas player props (coming soon)
- Early Army vs. Air Force prediction
- Army vs. Air Force prediction (coming soon)
- Early Georgia vs. Florida prediction
- Georgia vs. Florida prediction (coming soon)
- Georgia vs. Florida player props (coming soon)
- Oklahoma vs. Tennessee prediction (coming soon)
- USC vs. Nebraska prediction (coming soon)
- USC vs. Nebraska player props (coming soon)
- Washington State vs. Oregon State prediction (coming soon)
- Cincinnati vs. Utah prediction (coming soon)
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๐ฐ College football odds & expert picks: Friday
Here are the latest college football odds for every Week 10 game via the best college football betting sites, which update live in real time.
๐ Memphis vs. Rice odds
- Date: Friday, Oct. 31
- Kickoff: 7 p.m. ET
- Location: Rice Stadium (Houston)
- How to watch: ESPN2
๐ฎ Memphis vs. Rice prediction
🐅 Memphis -14 (-108)
Jeff Sagarinโs rankings favor Memphis by 21. The Fremeau Efficiency Index (FEI) favors Memphis by 17.5. I just donโt see Memphis fumbling an opportunity to make the college football playoff with a dud game versus Rice following such a massive victory over USF. Back the Tigers to cover the 14-point spread for -108 (51.9%) at DraftKings for a $9.26 profit on a $10 bet.
- via Isaiah Sirois' Memphis vs. Rice prediction
๐ North Carolina vs. Syracuse odds
- Date: Friday, Oct. 31
- Kickoff: 7:30 p.m. ET
- Location: JMA Wireless Dome (Syracuse, N.Y.)
- How to watch: ESPN
๐ฎ North Carolina vs. Syracuse prediction
⬇️ Under 45.5 (-110)
Neither of these teams is proficient at scoring, with both North Carolina and Syracuse's offense essentially ghosting their defensive head coaches all season. Both teams are worse at carving up defenses than your uncle is at carving a jack-o-lantern after a few too many cups of his "famous" spiked pumpkin spice hot chocolate.
๐ Sam Houston vs. Louisiana Tech odds
- Date: Friday, Oct. 31
- Kickoff: 8 p.m. ET
- Location: Joe Aillet Stadium (Ruston, La.)
- How to watch: CBSSN
๐ฎ Sam Houston vs. Louisiana Tech prediction
🐶 Louisiana Tech -16.5 (-112)
Six of Sam Houstonโs seven losses have been by at least 17 points, and the Bearkats have yet to score more than 24 in a road game while giving up at least 37 in all four such contests.
- via Phil Wood's Sam Houston vs. Louisiana Tech prediction
๐ฐ College football odds & expert picks: Saturday
๐ Penn State vs. Ohio State odds
- Date: Saturday, Nov. 1
- Kickoff: Noon ET
- Location: Ohio Stadium (Columbus, Ohio)
- How to watch: FOX
๐ฎ Penn State vs. Ohio State early prediction
🌰 Ohio State -20.5 (-110)
Last year, this was a matchup between top-five teams, with Ohio State winning by seven on the road. This year, it's in Columbus, and Penn State has completely fallen apart, firing James Franklin and losing four straight games. With the Buckeyes having the No. 1-ranked defense by SP+ and an offense led by Heisman contender Julian Sayin, the Nittany Lions don't stand a chance on the road with backup freshman QB Ethan Grunkemeyer behind center. The Buckeyes enter this game 6-0-1 ATS, while Penn State is just 1-6.
๐ Vanderbilt vs. Texas odds
- Date: Saturday, Nov. 1
- Kickoff: Noon ET
- Location: DKR-Texas Memorial Stadium (Austin, Texas)
- How to watch: ABC
๐ฎ Vanderbilt vs. Texas early prediction
⚓️ Vanderbilt +2.5 (-110)
While Texas' comeback OT win against Mississippi State in Week 9 was impressive, it was still a game the Longhorns failed to cover the spread in ... they're now 2-6 ATS. Meanwhile, Vanderbilt took down a ranked Missouri team to lift its ATS record to 6-2. With Arch Manning exiting Texas' win over the Bulldogs with a concussion, there's no guarantee he'll be able to play against the Commodores either. Back Diego Pavia to keep this close on the road with these teams both being ranked top 15 by SP+. Vanderbilt is 4-0 ATS this season when the spread is single digits either way.
๐ Army vs. Air Force odds
- Date: Saturday, Nov. 1
- Kickoff: Noon ET
- Location: Falcon Stadium (USAF Academy, Co.)
- How to watch: CBS, Paramount+
๐ฎ Army vs. Air Force early prediction
⬆️ Over 49.5 (-110)
But perhaps this trend of Unders is outdated, given that service academies have adapted their triple-option offense to become more pass-friendly. These teams air it out more than usual, and Army quarterback Cale Hellums has turned in his two highest QBR totals of the season despite his passing attempts increasing for three straight games.
- via Mike Spector's Early Army vs. Air Force prediction
๐ Georgia vs. Florida odds
- Date: Saturday, Nov. 1
- Kickoff: 3:30 p.m. ET
- Location: EverBank Stadium (Jacksonville, Fla.)
- How to watch: ABC
๐ฎ Georgia vs. Florida early prediction
⬇️ Under 50.5 (-110)
Both of these teams are allowing 20 or fewer points per game, and while Georgia is averaging 33.7 per contest, Florida is averaging just 22.4 (103rd in the nation). Considering how inept the Florida offense has looked at times this year, I expect this total to decrease as the week progresses.
- via Philip Wood's Early Georgia vs. Florida prediction
๐ Oklahoma vs. Tennessee odds
- Date: Saturday, Nov. 1
- Kickoff: 7:30 p.m. ET
- Location: Neyland Stadium, Knoxville (Tenn.)
- How to watch: ABC
๐ USC vs. Nebraska odds
- Date: Saturday, Nov. 1
- Kickoff: 7:30 p.m. ET
- Location: Memorial Stadium (Lincoln, Neb.)
- How to watch: NBC
๐ฎ USC vs. Nebraska early prediction
🗡️ USC -4.5 (-110)
While the rumor mill keeps churning about Matt Rhule taking the head coaching job at his alma mater, Penn State, Nebraska continues to look unimpressive. The Cornhuskers are 0-4-1 ATS in Big Ten games this season, and are just a few weeks removed from getting blown out by a Minnesota team that just lost by 38 to Iowa. As for USC, it's poised to bounce back off a bye week after losing to Notre Dame in Week 8. The Trojans are ranked No. 1 in the country in offense by SP+ thanks to Jayden Maiava and Makai Lemon, and have covered in two straight games against ranked teams.
๐ Washington State vs. Oregon State odds
- Date: Saturday, Nov. 1
- Kickoff: 7:30 p.m. ET
- Location: Reser Stadium (Corvallis, Ore.)
- How to watch: CBS
๐ Cincinnati vs. Utah odds
- Date: Saturday, Nov. 1
- Kickoff: 10:15 p.m. ET
- Location: Rice-Eccles Stadium (Salt Lake City)
- How to watch: ESPN
๐ก College football expert picks: Week 10
- College football picks against the spread Week 10
- College football player prop bets Week 10: Weekday best bets
- College football predictions for every top 25 game in Week 10
- College football player props Week 10 (coming soon)
- Big Ten best bets Week 10 (coming soon)
- SEC best bets Week 10 (coming soon)
- College football betting report Week 10 (coming soon)
- College football anytime touchdown scorer predictions Week 10 (coming soon)
- College football Week 10 schedule & watch guide (coming soon)
- College football best bets Week 10 (coming soon)
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