College Football Predictions Week 10: Best Bets & Odds for Friday

Check out the latest college football predictions and odds for Week 10, including our best bets and expert picks for Friday's three-game slate.
Syracuse Orange wide receiver Johntay Cook (2) celebrates after a touchdown as we offer our college football predictions for Week 10.
Pictured: Syracuse Orange wide receiver Johntay Cook (2) celebrates after a touchdown as we offer our college football predictions for Week 10. Photo by Brett Davis / Imagn Images.

As we head into the final few weeks of the regular season, our college football predictions for Week 10 focus on several key matchups from Weekday CUSA games to the Pac-2 showdown deep into Saturday night.

Our college football picks continue Friday with Memphis vs. Rice at 7 p.m. ET (ESPN2), North Carolina vs. Syracuse at 7:30 p.m. ET (ESPN), and Sam Houston vs. Louisiana Tech at 8 p.m. ET (CBSSN).


๐Ÿˆ College football predictions: Week 10

Here are all of our college football expert picks for Week 10, which we'll update throughout the week.

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๐Ÿ’ฐ College football odds & expert picks: Friday

Here are the latest college football odds for every Week 10 game via the best college football betting sites, which update live in real time.

๐Ÿ“Š Memphis vs. Rice odds

  • Date: Friday, Oct. 31
  • Kickoff: 7 p.m. ET
  • Location: Rice Stadium (Houston)
  • How to watch: ESPN2

๐Ÿ”ฎ Memphis vs. Rice prediction

🐅 Memphis -14 (-108)

Jeff Sagarinโ€™s rankings favor Memphis by 21. The Fremeau Efficiency Index (FEI) favors Memphis by 17.5. I just donโ€™t see Memphis fumbling an opportunity to make the college football playoff with a dud game versus Rice following such a massive victory over USF. Back the Tigers to cover the 14-point spread for -108 (51.9%) at DraftKings for a $9.26 profit on a $10 bet.

- via Isaiah Sirois' Memphis vs. Rice prediction


๐Ÿ“Š North Carolina vs. Syracuse odds

  • Date: Friday, Oct. 31
  • Kickoff: 7:30 p.m. ET
  • Location: JMA Wireless Dome (Syracuse, N.Y.)
  • How to watch: ESPN

๐Ÿ”ฎ North Carolina vs. Syracuse prediction

⬇️ Under 45.5 (-110)

Neither of these teams is proficient at scoring, with both North Carolina and Syracuse's offense essentially ghosting their defensive head coaches all season. Both teams are worse at carving up defenses than your uncle is at carving a jack-o-lantern after a few too many cups of his "famous" spiked pumpkin spice hot chocolate.

- via my North Carolina vs. Syracuse prediction


๐Ÿ“Š Sam Houston vs. Louisiana Tech odds

  • Date: Friday, Oct. 31
  • Kickoff: 8 p.m. ET
  • Location: Joe Aillet Stadium (Ruston, La.)
  • How to watch: CBSSN

๐Ÿ”ฎ Sam Houston vs. Louisiana Tech prediction

🐶 Louisiana Tech -16.5 (-112)

Six of Sam Houstonโ€™s seven losses have been by at least 17 points, and the Bearkats have yet to score more than 24 in a road game while giving up at least 37 in all four such contests.

- via Phil Wood's Sam Houston vs. Louisiana Tech prediction


๐Ÿ’ฐ College football odds & expert picks: Saturday

๐Ÿ“Š Penn State vs. Ohio State odds

  • Date: Saturday, Nov. 1
  • Kickoff: Noon ET
  • Location: Ohio Stadium (Columbus, Ohio)
  • How to watch: FOX

๐Ÿ”ฎ Penn State vs. Ohio State early prediction

🌰 Ohio State -20.5 (-110)

Last year, this was a matchup between top-five teams, with Ohio State winning by seven on the road. This year, it's in Columbus, and Penn State has completely fallen apart, firing James Franklin and losing four straight games. With the Buckeyes having the No. 1-ranked defense by SP+ and an offense led by Heisman contender Julian Sayin, the Nittany Lions don't stand a chance on the road with backup freshman QB Ethan Grunkemeyer behind center. The Buckeyes enter this game 6-0-1 ATS, while Penn State is just 1-6.


๐Ÿ“Š Vanderbilt vs. Texas odds

  • Date: Saturday, Nov. 1
  • Kickoff: Noon ET
  • Location: DKR-Texas Memorial Stadium (Austin, Texas)
  • How to watch: ABC

๐Ÿ”ฎ Vanderbilt vs. Texas early prediction

⚓️ Vanderbilt +2.5 (-110)

While Texas' comeback OT win against Mississippi State in Week 9 was impressive, it was still a game the Longhorns failed to cover the spread in ... they're now 2-6 ATS. Meanwhile, Vanderbilt took down a ranked Missouri team to lift its ATS record to 6-2. With Arch Manning exiting Texas' win over the Bulldogs with a concussion, there's no guarantee he'll be able to play against the Commodores either. Back Diego Pavia to keep this close on the road with these teams both being ranked top 15 by SP+. Vanderbilt is 4-0 ATS this season when the spread is single digits either way.


๐Ÿ“Š Army vs. Air Force odds

  • Date: Saturday, Nov. 1
  • Kickoff: Noon ET
  • Location: Falcon Stadium (USAF Academy, Co.)
  • How to watch: CBS, Paramount+

๐Ÿ”ฎ Army vs. Air Force early prediction

⬆️ Over 49.5 (-110)

But perhaps this trend of Unders is outdated, given that service academies have adapted their triple-option offense to become more pass-friendly. These teams air it out more than usual, and Army quarterback Cale Hellums has turned in his two highest QBR totals of the season despite his passing attempts increasing for three straight games.

- via Mike Spector's Early Army vs. Air Force prediction


๐Ÿ“Š Georgia vs. Florida odds

  • Date: Saturday, Nov. 1
  • Kickoff: 3:30 p.m. ET
  • Location: EverBank Stadium (Jacksonville, Fla.)
  • How to watch: ABC

๐Ÿ”ฎ Georgia vs. Florida early prediction

⬇️ Under 50.5 (-110)

Both of these teams are allowing 20 or fewer points per game, and while Georgia is averaging 33.7 per contest, Florida is averaging just 22.4 (103rd in the nation). Considering how inept the Florida offense has looked at times this year, I expect this total to decrease as the week progresses.

- via Philip Wood's Early Georgia vs. Florida prediction


๐Ÿ“Š Oklahoma vs. Tennessee odds

  • Date: Saturday, Nov. 1
  • Kickoff: 7:30 p.m. ET
  • Location: Neyland Stadium, Knoxville (Tenn.)
  • How to watch: ABC

๐Ÿ“Š USC vs. Nebraska odds

  • Date: Saturday, Nov. 1
  • Kickoff: 7:30 p.m. ET
  • Location: Memorial Stadium (Lincoln, Neb.)
  • How to watch: NBC

๐Ÿ”ฎ USC vs. Nebraska early prediction

🗡️ USC -4.5 (-110)

While the rumor mill keeps churning about Matt Rhule taking the head coaching job at his alma mater, Penn State, Nebraska continues to look unimpressive. The Cornhuskers are 0-4-1 ATS in Big Ten games this season, and are just a few weeks removed from getting blown out by a Minnesota team that just lost by 38 to Iowa. As for USC, it's poised to bounce back off a bye week after losing to Notre Dame in Week 8. The Trojans are ranked No. 1 in the country in offense by SP+ thanks to Jayden Maiava and Makai Lemon, and have covered in two straight games against ranked teams.


๐Ÿ“Š Washington State vs. Oregon State odds

  • Date: Saturday, Nov. 1
  • Kickoff: 7:30 p.m. ET
  • Location: Reser Stadium (Corvallis, Ore.)
  • How to watch: CBS

๐Ÿ“Š Cincinnati vs. Utah odds

  • Date: Saturday, Nov. 1
  • Kickoff: 10:15 p.m. ET
  • Location: Rice-Eccles Stadium (Salt Lake City)
  • How to watch: ESPN

๐Ÿ’ก College football expert picks: Week 10


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